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A rigorous industrial perspective on molecular specifications, synthesis optimization, global compliance, and procurement intelligence.
4-Bromophenylacetonitrile (CAS Numbers: 16532-79-9 / 4468-48-8) is a paramount organobromine building block utilized in advanced organic synthesis, active pharmaceutical ingredient (API) development, and fine chemical manufacturing. Featuring a bifunctional structural motif—combining a reactive benzylic nitrile carbon with an electrophilic para-brominated aromatic ring—it acts as an essential intermediate for cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) and nucleophilic substitutions.
Achieving ultra-high purity levels in wholesale manufacturing is imperative. Traces of ortho/meta isomers or unreacted 4-bromotoluene can compromise downstream reaction yields and lead to genotoxic impurity profiles in final medicinal products.
Our industrial production lines enforce stringent In-Process Controls (IPC) to guarantee lot-to-lot consistency. Below is the analytical parameter breakdown standard for bulk export batches:
| Analytical Parameter | Specification Standard |
|---|---|
| Chemical Formula | C₈H₆BrN |
| Molecular Weight | 196.04 g/mol |
| Appearance | White to off-white crystalline solid / liquid (ambient) |
| Assay (HPLC) | ≥ 99.0% (Specialized grades: ≥ 99.5%) |
| Melting Point | 47.0 °C to 51.0 °C |
| Moisture Content (Karl Fischer) | ≤ 0.5% |
| Single Impurity (HPLC) | ≤ 0.3% |
E-E-A-T Quality Commitment: Gentolex utilizes continuous flow bromination and automated cyanide displacement systems, eliminating batch-to-batch thermal spikes and ensuring structural isomer purity below 0.10%. Full analytical support including ¹H-NMR, GC-MS, and LC-MS certificates of analysis (CoA) accompany all bulk commercial deliveries.
China's chemical sector provides unmatched industrial integration for raw materials like bromine derivatives and acetonitrile salts. Operating within integrated industrial chemical parks, Gentolex leverages raw material proximity to guarantee price stability, secure batch volume scalability, and mitigate international supply bottlenecks. Our 250,000 m² construction infrastructure ensures high batch-size flexibility ranging from pilot-scale (50kg) to multi-ton commercial orders.
Procuring fine chemicals internationally requires seamless regulatory compliance. Gentolex supports multinational enterprise procurement by providing full EHS compliance, REACH registration support for European Union markets, US TSCA registration clarity, and GHS-compliant UN-certified hazard packaging (Class 6.1 toxic/corrosive standards). Dedicated Quality Assurance teams oversee documentation, including Material Safety Data Sheets (MSDS/SDS) in multiple languages.
The global fine chemical industry is transitioning rapidly toward green chemistry practices and continuous manufacturing processes. Modern 4-Bromophenylacetonitrile synthesis focuses on reducing heavy metal catalyst residue, recycling brominated by-products, and applying continuous flow micro-reactors. This operational shift lowers carbon emissions, minimizes thermal runaway risks, and achieves optimal atom economy, setting new standards for sustainable chemical sourcing.
How global pharmaceutical research centers, agricultural chemical producers, and material scientists leverage 4-Bromophenylacetonitrile.
Serves as a pivotal precursor for cardiovascular, neuroactive, and anti-inflammatory pharmaceutical agents. The alpha-position carbon allows smooth alkylation to construct complex medicinal scaffolds including piperidine and pyrrolidine derivatives.
Utilized in the synthesis of high-efficiency broad-spectrum fungicides, herbicides, and crop protection chemicals. The bromine handle facilitates aryl-coupling pathways to yield resilient bio-active pest control compounds.
Applied in material chemistry for preparing conjugated organic polymers, liquid crystal displays (LCDs), and organic light-emitting diode (OLED) semiconductors due to its rigid phenyl-nitrile structural backbones.
Connecting global markets with technical consultation, guaranteed product line setup, and specialized supply chain integration.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Integrated chemical synthesis research, route optimization, impurity profiling, and analytical standard preparation for worldwide R&D clients.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Partnering with accredited pharmaceutical laboratories and commercial buyers worldwide.
Latest research updates, peptide synthesis insights, and API market analyses.
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