High-Quality Daptomycin 103060-53-3 for Infectious Diseases Suppliers, Companies

Name: Daptomycin CAS number: 103060-53-3 Molecular formula: C72H101N17O26 Molecular weight: 1620.67 EINECS Number: 600-389-2 Melting point: 202-204°C Boiling point: 2078.2±65.0 °C (Predicted) Density: 1.45±0.1 g/cm3(Predicted) Flash point: 87℃

Product Description

Product Specifications

Name Daptomycin
CAS number 103060-53-3
Molecular formula C72H101N17O26
Molecular weight 1620.67
EINECS Number 600-389-2
Melting point 202-204°C
Boiling point 2078.2±65.0 °C (Predicted)
Density 1.45±0.1 g/cm3 (Predicted)
Flash point 87℃
Storage conditions Sealed in dry, Store in freezer, under -20°C
Solubility Methanol: soluble 5mg/mL
Acidity coefficient (pKa) 4.00±0.10 (Predicted)
Form powder
Color colorless to faint yellow

Chemical Names & Synonyms

N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-]; N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-]; N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE; Dapcin; Daptomycin, >=99%; DaptomycinReadyMadeSolution; Daptomycin(LY146032)

Overview & Mechanism of Action

The antibiotic daptomycin is a cyclic lipopeptide antibiotic with a new structure extracted from the fermentation broth of Streptomyces (S. roseosporus), which hinders the biosynthesis of bacterial cell wall peptidoglycan by disturbing the transport of amino acids in the cell membrane. Altering the properties of the cytoplasmic membrane can disrupt bacterial membrane function in multiple ways and rapidly kill Gram-positive bacteria. In addition to its ability to act on most clinically relevant Gram-positive bacteria, daptomycin is more important for isolated strains that have shown resistance to methicillin, vancomycin, and linezolid in vitro. It has potent activity, and this property has very important clinical implications for critically ill infected patients. Eosinophilic pneumonia is a rare and very serious disease with symptoms including fever, cough, shortness of breath, and difficulty breathing.

Bacteriostatic & Antibacterial Activity

Daptomycin has good bacteriostatic activity against various antibiotic-resistant bacteria, such as MIC=0.06-0.5 μg/ml for methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus aureus (MRSA). MIC=0.0625~1μg/ml for bacteria, MIC=0.12~0.5μg/ml for oxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml for enterococcus highly resistant to aminoglycoside antibiotics, MIC=2.5μg/ml for GmrBIa -The MIC of Enterococcus is 0.5~1μg/ml, and the MIC of Enterococcus resistant to glycopeptide antibiotics is 1~2μg/ml.

Frequently Asked Questions (FAQ)

Q1 What is Daptomycin and how is it derived?

Daptomycin is a cyclic lipopeptide antibiotic with a unique structure extracted from the fermentation broth of Streptomyces (S. roseosporus).

Q2 How does Daptomycin work against bacteria?

It hinders the biosynthesis of bacterial cell wall peptidoglycan by disturbing amino acid transport in the cell membrane. By altering cytoplasmic membrane properties, it disrupts bacterial membrane function in multiple ways to rapidly kill Gram-positive bacteria.

Q3 What are the recommended storage conditions for Daptomycin?

It should be kept sealed in a dry place and stored in a freezer under -20°C.

Q4 What is the MIC of Daptomycin for methicillin-resistant Staphylococcus aureus (MRSA)?

The Minimum Inhibitory Concentration (MIC) for methicillin-resistant Staphylococcus aureus (MRSA) ranges from 0.06 to 0.5 μg/ml.

Q5 Why is Daptomycin clinically significant for critically ill patients?

It possesses potent activity against isolated bacterial strains that exhibit resistance to key antibiotics such as methicillin, vancomycin, and linezolid in vitro.

Q6 What are the physical form and color appearance of Daptomycin?

Daptomycin appears in powder form, ranging in color from colorless to faint yellow.

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