Direct factory sourcing with certified cGMP quality assurance, analytical documentation, and global cold-chain distribution.
Understanding the biological mechanism, structural specs, and procurement parameters for high-purity Mitochondrial-Derived Peptides.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) represents a paradigm shift in metabolic peptide chemistry. Derived directly from the mitochondrial genome rather than nuclear DNA, MOTS-c is a naturally occurring 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene. Its precise primary amino acid sequence is structured as follows:
H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-NH2
With a molecular formula of C101H152N28O22S2 and a monoisotopic molecular weight of approximately 2174.62 Da, MOTS-c acts as a powerful metabolic signaling agent. Upon metabolic strain or cellular stress, MOTS-c translocates from the mitochondria to the nucleus, where it binds to specific genomic regions to regulate cellular homeostasis, glucose utilization, and bioenergetic capacity.
Research indicates that MOTS-c plays a direct role in activating the AMP-activated protein kinase (AMPK) pathway. By enhancing cellular levels of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase inhibitors, MOTS-c drives metabolic adaptations similar to endurance physical exercise and caloric restriction. This makes MOTS-c 20mg highly sought after by clinical research organizations (CROs), anti-aging academic centers, and advanced biopharmaceutical innovators.
Stimulates cellular energy expenditure, restores insulin sensitivity, and promotes mitochondrial biogenesis in skeletal muscle tissue.
Translocates under metabolic stress to bind nuclear DNA, regulating systemic adaptive stress responses and cellular survival pathways.
Pharmaceutical-grade 20mg vials demand stringent lyophilization protocols, guaranteeing minimal salt residues for high-precision assays.
Standard operating procedures for solid-phase peptide synthesis (SPPS), purification, and analytical verification of MOTS-c 20mg.
Producing MOTS-c at a commercial 20mg scale with pure sequence integrity requires specialized expertise. Due to the presence of hydrophobic residues (Met, Trp, Ile, Phe, Leu) and basic residues (Arg, Lys), aggregation during peptide chain elongation can lead to deletion sequences if chemistry is not meticulously controlled.
At Gentolex Chemicals, we employ advanced Fmoc/tBu solid-phase peptide synthesis utilizing automated microwave-assisted synthesizers. This technology minimizes steric hindrance and accelerates coupling reaction kinetics for hard-to-synthesize sequences.
| Analytical Parameter | Testing Protocol | Acceptance Criteria (Research & API Grade) |
|---|---|---|
| Chemical Purity | Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) | ≥ 98.0% – 99.5% (Peak Area Integration) |
| Mass Identification | Electrospray Ionization Mass Spectrometry (ESI-MS) / MALDI-TOF | Conforms to target mass: 2174.62 ± 1.0 Da |
| Counter-Ion Content | Ion Chromatography / HPLC | TFA content < 1.0%; Acetate exchange option available (< 0.5%) |
| Bacterial Endotoxins | Limulus Amebocyte Lysate (LAL) Kinetic Chromogenic Method | < 0.05 EU/mg (Ultra-pure formulation) |
| Moisture Content | Karl Fischer Titration | ≤ 5.0% (Optimized post-lyophilization) |
| Residual Solvents | Gas Chromatography Headspace (GC-HS) | Meets ICH Q3C Guidelines for Class 2 & 3 solvents |
The stability of MOTS-c is highly dependent on the final freeze-drying (lyophilization) cycle. A slow, multi-stage secondary drying process ensures moisture levels remain strictly under 5%. The 20mg dosage is freeze-dried into a uniform, non-collapsible cake inside Type I borosilicate glass vials, sealed under inert nitrogen atmosphere with bromobutyl rubber stoppers and flip-off aluminum caps. This preserves bioactivity across long-distance international cold-chain transit.
Leveraging smart manufacturing, fully automated production lines, and continuous raw material integration.
Our facility utilizes Industry 4.0 integration—linking real-time IoT synthesis tracking with liquid chromatography purification arrays. This automation reduces human handling errors, guarantees batch reproducibility, and cuts synthesis lead times by up to 40% compared to traditional peptide manufacturing methods.
Gentolex Chemicals directly controls upstream raw material production—including specialized Fmoc amino acids, coupling reagents (HATU, PyBOP), and resins. This vertical integration buffers our clients against global supply chain disruptions, stabilizing pricing for bulk MOTS-c 20mg orders.
Customized procurement frameworks for CROs, compounding centers, and global distributors.
Enterprise procurement teams seeking to Buy MOTS-c 20mg suppliers and companies require comprehensive operational flexibility beyond raw catalog items. Gentolex Chemicals provides structured contract manufacturing services tailored to corporate purchasing workflows.
From custom vial crimping and color-coded flip caps to private labeling and specialized outer box packaging, we deliver shelf-ready commercial options.
Temperature-monitored international shipping via validated insulated packaging, gel ice packs, or dry-ice systems ensuring non-degraded arrival globally.
Every single production batch includes comprehensive CoA (Certificate of Analysis), HPLC chromatograms, MS spectra, and safety data sheets (MSDS).
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions. Whether establishing a new peptide analytical laboratory or seeking reliable bulk active pharmaceutical ingredients, Gentolex delivers proven expertise across the value chain.
Gentolex's goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard allows us to offer flexible, scalable and cost-effective solutions. Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
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Gentolex Chemicals supplies MOTS-c 20mg at a standard HPLC purity threshold of ≥98.0%, with premium batches exceeding 99.2%. Every order is accompanied by comprehensive analytical documentation including HPLC chromatograms and Electrospray Ionization Mass Spectrometry (ESI-MS) reports verification.
The 20mg vial format offers superior cost-efficiency for high-throughput screening, longitudinal laboratory studies, and large-scale experimental models. It reduces per-milligram packaging overhead while optimizing freeze-drying cake stability and reconstitutability.
Standard peptide synthesis leaves residual TFA salts which can affect sensitive biological assays. Gentolex offers specialized ion-exchange chromatography to convert TFA salts into acetate or hydrochloride salts, reducing TFA content below 1.0% or to non-detectable levels upon request.
Lyophilized MOTS-c 20mg should be stored at -20°C for long-term stability (up to 24 months). Protect from light and moisture exposure. Once reconstituted with sterile bacteriostatic water or PBS buffer, solutions should be kept at 2°C to 8°C and utilized within 7 to 14 days.
Yes, we provide full OEM/ODM contract manufacturing services. Clients can customize vial volumes, cap styles, custom outer boxes, customized batch labeling, and select tailored fill-finish specifications under strict confidentiality agreements (NDAs).
Direct factory supply of metabolic, therapeutic, and specialty intermediate APIs.
