Buy 2 Bromoethylamine Hydrobromide Manufacturers & Suppliers

Chemical Profile & Molecular Structure

2-Bromoethylamine Hydrobromide (CAS No: 2576-47-8), frequently abbreviated as 2-BEA HBr, is a versatile bifunctional chemical intermediate containing both a halogenated alkyl group and a hydrobromide-stabilized primary amine. Its molecular formula is C₂H₇Br₂N (or C₂H₆BrN·HBr), with a molecular weight of approximately 204.89 g/mol. Visually, pure 2-Bromoethylamine Hydrobromide exists as a white to off-white crystalline powder with high solubility in polar solvents such as water and lower alcohols.

The strategic value of 2-bromoethylamine hydrobromide in modern synthetic chemistry stems from its dual functionality. The electrophilic carbon atom attached to the bromine atom readily undergoes nucleophilic substitution reactions, while the primary amine moiety (protected as an ammonium salt) prevents premature self-condensation or polymerization during alkylation processes. This renders it an ideal reagent for introducing two-carbon amine linkages into complex biological molecules, pharmaceutical APIs, and specialty polymers.

Synthetic Pathways & Industrial Manufacturing Process

Commercial production of 2-bromoethylamine hydrobromide involves controlled reaction mechanisms designed to optimize yield while minimizing hazardous byproducts:

• Hydrobromination of Ethanolamine: Ethanolamine reacts with concentrated hydrobromic acid (HBr) under elevated temperature and reflux conditions. The hydroxyl group undergoes substitution by bromine via nucleophilic attack, followed by salt formation with excess hydrobromic acid to stabilize the terminal amine.
• Aziridine Ring Opening: Reaction of aziridine (ethyleneimine) with hydrobromic acid serves as an alternative high-yield route in continuous flow microreactors, allowing precise exothermic temperature regulation and superior product purity.
• Purification via Recrystallization: Industrial-scale purification relies on controlled crystallization using ethanol-isopropanol or water-solvent mixtures to eliminate trace impurities, unreacted HBr, and inorganic salts, delivering a guaranteed assay purity of ≥ 99.0%.

Quality Specifications & HPLC Purity Control

At Gentolex Group, our quality control procedures adhere to rigorous global standardizations (cGMP, ISO 9001, ISO 14001). Every manufactured batch of 2-Bromoethylamine Hydrobromide undergoes comprehensive analytical validation prior to global dispatch:

Handling, Storage & Regulatory Classification

2-Bromoethylamine Hydrobromide is classified as a hazardous chemical due to its corrosive and hygroscopic nature. Proper industrial handling protocols must be observed:

• UN Classification: UN 3261 (Corrosive Solid, Acidic, Organic, N.O.S.), Hazard Class 8, Packing Group II.
• Storage Conditions: Keep in tightly sealed containers stored in a cool, dry, well-ventilated location away from strong bases, oxidizers, and direct moisture. Storage temperature should be maintained below 25 °C (or 2-8 °C for extended shelf life).
• Personnel Safety: Operators must utilize NIOSH-approved respirators, chemical-resistant gloves (nitrile or neoprene), safety goggles, and full protective lab garments. Ensure local exhaust ventilation is operational during powder transfer.