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PT-141 (Bremelanotide) is a synthetic peptide that activates melanocortin receptors (MC3/MC4) in the brain. Unlike PDE-5 inhibitors, it works through the central nervous system rather than blood flow. It is FDA-approved for hypoactive sexual desire disorder (HSDD) in women and is commonly used on an on-demand basis.
Vial strength: 10 mg lyophilized powder
PT-141 is typically used as needed, not daily.
| Purpose | Dose | Volume | U-100 Syringe Units |
|---|---|---|---|
| FDA-recommended dose | 1.75 mg (1750 mcg) | 0.53 mL | ~53 units |
| Moderate starting dose | 1.0 mg (1000 mcg) | 0.30 mL | ~30 units |
| Conservative / first-time dose | 0.5 mg (500 mcg) | 0.15 mL | ~15 units |
Timing:
For smaller doses (≤0.15 mL), a 30- or 50-unit syringe improves accuracy.
| State | Storage |
|---|---|
| Unreconstituted powder | −20 °C (freezer), dry & dark |
| Reconstituted solution | 2–8 °C (refrigerator) |
| Shelf life (mixed) | Best used within 30 days |
| Avoid | Repeated freeze-thaw cycles |
Usually mild and temporary:
Starting at a lower dose can help reduce side effects.