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4′-Trifluoromethyl-Biphenyl-4-Carbaldehyde (CAS Number: 92965-38-1) is a critical trifluoromethylated aromatic aldehyde serving as a highly reactive building block in fine chemical synthesis, advanced pharmaceutical intermediates, liquid crystal optoelectronic materials, and peptide coupling applications. Incorporating a lipophilic trifluoromethyl (-CF3) group alongside a biaryl backbone, this molecule offers enhanced metabolic stability, strong electron-withdrawing dynamics, and unique liquid crystal phase transitions.
| Property Parameter | Technical Specification | Analytical Method / Standard |
|---|---|---|
| Chemical Name | 4′-(Trifluoromethyl)[1,1′-biphenyl]-4-carboxaldehyde | IUPAC Nomenclature |
| CAS Registry Number | 92965-38-1 | CAS Chemical Index |
| Molecular Formula | C14H9F3O | Elemental Mass Spectrometry |
| Appearance | White to Off-White Crystalline Powder | Visual Inspection |
| Assay / Purity | ≥ 99.0% (Commercial) / ≥ 99.5% (Pharma Grade) | HPLC (High-Performance Liquid Chromatography) |
| Melting Point | 74.0 °C to 78.0 °C | Capillary Melting Apparatus |
| Moisture Content (LOD) | ≤ 0.5% | Karl Fischer Titration |
| Heavy Metals Standard | ≤ 10 ppm | ICP-MS Analysis |
As a leading factory-direct supplier, Gentolex utilizes optimized green chemistry protocols and high-yield catalytic routes to manufacture bulk quantities of 4′-Trifluoromethyl-Biphenyl-4-Carbaldehyde with strict batch-to-batch consistency.
The primary industrial route involves the transition-metal-catalyzed cross-coupling of 4-trifluoromethylphenylboronic acid with 4-bromobenzaldehyde. Utilizing palladium catalysts (e.g., Pd(PPh3)4 or Pd(dppf)Cl2) in an aqueous-organic biphasic system ensures conversion efficiencies exceeding 96% with minimal deboronation byproducts.
For ultra-high purity requirements, cryogenic organometallic synthesis is deployed. Direct halogen-metal exchange of 4-bromo-4′-(trifluoromethyl)biphenyl with n-butyllithium followed by quenching with anhydrous N,N-dimethylformamide (DMF) produces raw aldehyde with low structural isomer contamination.
Gentolex operates modern micro-reactor continuous flow setups for large-scale procurement. Continuous processing minimizes residence time, reduces hazardous waste streams, precise temperature control avoids thermal degradation, and guarantees superior batch scalability up to multi-ton lots.
Rigorous purity verification of fluorinated aromatics and organoboron reagents to prevent trace heavy metal contamination in downstream active pharmaceutical ingredients.
Precision-controlled atmosphere (nitrogen blanket) and automated temperature gradients optimize ligand conversion rates and reduce homocoupling side-products.
Multi-stage solvent recrystallization yields high-density crystalline solid with tight particle distribution, ideal for automated weighing and industrial reactions.
The insertion of trifluoromethyl (-CF3) groups into organic frameworks significantly modifies molecular lipophilicity, metabolic stability, and dipolar moments. 4′-Trifluoromethyl-Biphenyl-4-Carbaldehyde acts as a core precursor across key modern industries:
Used extensively in pharmaceutical R&D for synthesizing novel oncology agents, anti-hypertensive therapeutics, and metabolic modulators. In custom peptide synthesis and bio-conjugation, the biphenyl aldehyde motif serves as a lipophilic hydrophobic cap or rigid turn-inducing moiety, enhancing serum stability and cellular penetration of therapeutic peptides.
Fluorinated biphenyl building blocks are essential precursors for high-performance liquid crystal mixtures and Organic Light-Emitting Diode (OLED) host materials. The strongly polar aldehyde group allows chemical functionalization into conjugated chromophores, improving dielectric anisotropy, thermal endurance, and luminescence efficiency in display tech.
Incorporated into next-generation fungicides, insecticides, and herbicides. Fluorine-containing biaryl intermediates confer high target selectivity, lower dosage requirements, and enhanced environmental resistance against micro-organism enzymatic degradation.
Serves as a key aldehyde partner in reductive amination, Wittig olefination, and Schiff base condensation reactions to construct sterically hindered phosphine ligands, chiral catalysts, and metal-organic frameworks (MOFs).
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions for intermediate raw materials and custom fine chemicals.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Full documentation and certificates (CoA, MSDS, DMF) are supported to customers worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
To meet strict regulatory audits from global pharmaceutical and chemical partners, every batch of 4′-Trifluoromethyl-Biphenyl-4-Carbaldehyde undergoes rigorous multi-stage quality testing.
All fluorinated aldehyde shipments comply with international IMDG and IATA air freight regulations. Product is sealed in double anti-static moisture-proof PE bags enclosed within UN-approved fiber drums (1kg, 5kg, 25kg bulk containers). Samples and commercial orders receive complete batch-specific Certificates of Analysis (CoA), Safety Data Sheets (SDS), and REACH compliance declarations upon request.
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