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An authoritative chemical engineering evaluation of CAS 86-29-3 as a crucial synthone in global active pharmaceutical ingredients (APIs) and advanced organic manufacturing.
Diphenylacetonitrile (CAS Number: 86-29-3, IUPAC name: 2,2-diphenylacetonitrile), also known as alpha-phenylbenzeneacetonitrile, stands as a fundamental organic building block within contract manufacturing organizations (CMO) and original equipment manufacturers (OEM) worldwide. Characterized by its robust nitrile group coupled with two sterically demanding phenyl rings, this compound serves as a highly versatile intermediate for nucleophilic substitution, alkylation, dynamic carbon-carbon bond formations, and catalytic hydrogenation processes.
Key Chemical Specifications: Molecular Formula: C14H11N | Molecular Weight: 193.24 g/mol | Appearance: White to off-white crystalline powder | Assay Purity: ≥ 99.5% (GC/HPLC) | Melting Point: 73.0 °C to 76.0 °C | Solubilities: Soluble in Ethanol, Chloroform, Ether, Methanol; insoluble in water.
The alpha-proton of Diphenylacetonitrile exhibits marked acidity (pKa ≈ 17.5 in DMSO) due to the synergistic electron-withdrawing resonance stabilization afforded by both the cyanic (-CN) functionality and the adjacent aromatic pi-systems. Under basic catalysis—utilizing reagents such as sodium hydride (NaH), sodium amide (NaNH2), or potassium tert-butoxide (t-BuOK)—the formed carbanion readily reacts with alkyl halides, epoxides, and carbonyl substrates. This reactivity renders OEM Diphenylacetonitrile an essential precursor in high-yield multi-step industrial synthesis.
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Detailed breakdown of downstream products, pharmaceutical active principles, and agricultural crop protection chemicals derived from Diphenylacetonitrile.
OEM Diphenylacetonitrile is predominantly consumed in the synthesis of essential gastrointestinal, analgesic, and central nervous system (CNS) medications. Notable drug targets include:
In modern agricultural crop protection chemistry, diphenylacetonitrile operates as a critical precursor for herbicides and plant growth regulators. A key example is Diphenamid (N,N-dimethyl-2,2-diphenylacetamide), a selective pre-emergence herbicide used extensively in tobacco, tomato, pepper, and berry cultivation to suppress broadleaf weeds and annual grasses.
Beyond pharmaceutical APIs and agrochemicals, OEM Diphenylacetonitrile derivative products play an indispensable role in UV-absorbers, polymer stabilizers, high-density optical resins, and phase-transfer catalysts. Its nitrile functional group can be selectively hydrolyzed into carboxylic acids, reduced into primary amines, or converted into tetrazoles for heterocyclic chemical research.
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The global OEM Diphenylacetonitrile market is undergoing rapid evolution driven by stringent environmental regulations, shifting pharmaceutical outsourcing strategies, and the demand for higher purity standards in continuous manufacturing. Key market drivers include:
Pharmaceutical buyers require chemical partners capable of guaranteeing multi-ton delivery without batch-to-batch variance. Impurities such as unreacted Benzhydrol or mono-phenyl derivatives can compromise API yield and regulatory approval. Gentolex enforces strict GC-MS and HPLC monitoring to ensure trace impurity profiles remain below 0.05%.
With operational bases in North America, Latin America (Mexico), and Africa (South Africa), Gentolex satisfies regional environmental protocols including REACH (Europe), TSCA (USA), and local OSHA safety frameworks. Our documentation packet includes complete Material Safety Data Sheets (MSDS), certificates of analysis (COA), and continuous route optimization reports.
The future of OEM Diphenylacetonitrile manufacturing relies on continuous flow micro-reactor technology and sustainable green catalytic frameworks. Transitioning from batch reactors to continuous flow micro-channel networks permits tighter thermal control during exothermic nitrilation reactions, yielding dramatic enhancements in safety profiles, energy consumption reduction, and atom economy.
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View Article DetailsDirect technical answers regarding OEM Diphenylacetonitrile uses, handling, purity standards, and global purchasing processes.
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