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An authoritative analysis of CAS 1122-91-4: Purity standards, synthetic utility in Suzuki-Miyaura coupling, regulatory compliance, and industrial manufacturing dynamics.
In the contemporary landscape of high-value chemical synthesis, 4-Bromobenzaldehyde (CAS 1122-91-4) occupies a pivotal position as an indispensable organic intermediate. Serving as a crucial building block across pharmaceutical active pharmaceutical ingredient (API) development, organic light-emitting diode (OLED) material synthesis, and modern agrochemical formulations, securing a high-purity, reliable supply of 4-Bromobenzaldehyde is essential for research laboratories and industrial chemical manufacturers alike.
As leading chemical engineering teams and procurement executives evaluate global sourcing channels, selecting a certified 4-Bromobenzaldehyde supplier and factory requires scrutiny beyond commercial pricing. Analytical consistency, trace impurity profiling, isomer control, packaging stability, and regulatory compliance (such as EU REACH, US TSCA, and cGMP standards for downstream APIs) are the fundamental parameters that dictate batch yield, reaction selectivity, and overall production efficiency.
Below is the benchmark analytical specification matrix maintained by Gentolex for commercial-grade and pharmaceutical-grade 4-Bromobenzaldehyde manufacturing batches:
| Property / Parameter | Standard Specification | Testing Methodology / Analytical Instrument |
|---|---|---|
| Chemical Name | 4-Bromobenzaldehyde (p-Bromobenzaldehyde) | IUPAC Nomenclature Standard |
| CAS Registry Number | 1122-91-4 | Chemical Abstracts Service Identification |
| Molecular Formula / Weight | C7H5BrO / 185.02 g/mol | Mass Spectrometry (MS) Verified |
| Appearance | White to light-yellow crystalline powder or flakes | Visual Inspection |
| Purity (Assay) | ≥ 99.5% (High-Purity Grade) | GC-FID / HPLC Normalized Area |
| Melting Point | 55.0 °C – 58.0 °C | Automated Melting Point Apparatus |
| Moisture Content (Karl Fischer) | ≤ 0.2% max | Coulometric Karl Fischer Titration |
| Individual Impurity (2- or 3-Isomers) | ≤ 0.10% | High-Resolution Gas Chromatography (GC) |
| Heavy Metal Residues | ≤ 10 ppm | ICP-MS Inductively Coupled Plasma |
Understanding how commercial synthesis routes impact product quality, impurity profiles, and downstream reactivity.
Industrial synthesis traditionally utilizes catalytic bromination of benzaldehyde or oxidative bromination of 4-bromotoluene. Gentolex employs advanced continuous-flow microchannel reactors that minimize over-bromination side reactions, effectively restricting 3,4-dibromobenzaldehyde byproducts to under 0.05%.
Position isomers (ortho- and meta-bromobenzaldehyde) possess nearly identical boiling points, making classical fractional distillation difficult. Our multi-stage fractional crystallization process guarantees meta/ortho isomer suppression, protecting critical cross-coupling reactions from regio-isomer contamination.
Every commercial shipment of 4-Bromobenzaldehyde is accompanied by full regulatory documentation, including Lot-Specific Certificate of Analysis (CoA), 1H-NMR spectrum validation, GC-MS fragmentation verification, and detailed heavy metal testing metrics for global compliance.
From lifesaving active pharmaceuticals to cutting-edge electronic display substrates.
The aryl bromide moiety of 4-Bromobenzaldehyde offers optimal reactivity in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. It is widely utilized as a key starting material for synthesizing biaryl scaffolds in anti-hypertensive agents, oncological kinase inhibitors, and antiviral therapeutics.
In the electronic chemical domain, p-bromobenzaldehyde is condensed into triarylamine derivative precursors, thermally stable host materials, and blue-emitting fluorophores for next-generation OLED mobile display panels and semiconductor coatings.
Used extensively in the synthesis of novel broad-spectrum fungicides, selective herbicides, and synthetic pyrethroid intermediates where the 4-bromophenyl aldehyde backbone provides crucial metabolic stability and targeted bioactivity.
Unlocking cost competitiveness, raw material security, and massive production capacity through modern industrial infrastructure.
China’s fully integrated chemical industrial parks grant direct pipeline access to liquid bromine and toluene feedstocks. This upstream integration insulates global buyers from volatile spot market price spikes and ensures uninterrupted bulk manufacturing.
Our standardized production infrastructure spans a total factory area of 250,000 square meters. Operating under international standards, Gentolex delivers flexible, scalable batch production ranging from 100 kg pilot scale up to multi-ton commercial orders.
Outfitted with advanced triple-effect evaporators, closed-loop bromine recycling systems, and RTO gas incinerators, our factories meet stringent environmental protection laws, ensuring stable long-term production without regulatory shutdown risks.
Ensuring product integrity through inert atmosphere packaging, cold-chain options, and international freight readiness.
Global pharmaceutical corporations and chemical distributors in Europe, North America, Mexico, South Africa, and Asia-Pacific require stringent transport stability when procuring 4-Bromobenzaldehyde. Because aldehyde moieties are inherently susceptible to air oxidation into 4-bromobenzoic acid over extended transport, Gentolex executes precise packaging protection protocol.
Overcoming cross-border regulatory barriers with localized service hubs and international standards alignment.
Navigating global regulatory frameworks requires an experienced manufacturing partner. Gentolex Group actively supports global clients with comprehensive regulatory dossiers and dedicated regional representation:
Emerging demand drivers shaping the global 4-Bromobenzaldehyde chemical ecosystem.
As targeted peptide therapeutics and novel drug delivery vectors expand rapidly, brominated aromatic linkers derived from 4-Bromobenzaldehyde are seeing increased adoption in drug-linker conjugation chemistry.
Industrial chemical factories are transitioning from traditional batch reactors to continuous flow micro-reactors, improving safety in bromination reactions while sharply reducing batch-to-batch variance.
Global buyers increasingly mandate eco-friendly supplier audits. Closed-loop bromination processes and solvent recovery systems are now standard criteria for contract renewal among top tier pharma procurement boards.
Gentolex’s overarching mission is to create strategic opportunities connecting global industries with superior services and guaranteed chemical products. To date, Gentolex Group serves valued clients across more than 10 countries, supported by dedicated representative offices in Mexico and South Africa.
Our core integrated services encompass:
An overall factory construction area of 250,000 square meters built to international standards, delivering flexible, scalable, and cost-effective chemical supply solutions.
Extensive portfolio of APIs and intermediates for development and commercial applications produced under cGMP standards from long-term verified collaborations.
Contract research and custom synthetic route scouting for complex heterocyclic molecules and specialized brominated aromatics.
Streamlined procurement management allowing global partners to centralize supply chain operations with single-point contact reliability.
Technical insights, API release updates, and pharmaceutical peptide developments from Gentolex specialists.
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View Details →Addressing key procurement, chemical handling, purity validation, and shipping inquiries for 4-Bromobenzaldehyde.
Our standard commercial manufacturing batches guarantee a minimum assay of ≥99.5% purity by HPLC/GC analysis. We also offer high-purity pharmaceutical grades with strictly controlled individual impurities (≤0.10%) upon request.
4-Bromobenzaldehyde oxidizes slowly when exposed to air. To preserve compound integrity, we package all shipments under an inert nitrogen atmospheric blanket inside double sealed anti-static polyethylene bags within UN-certified fiber or steel drums.
Yes, we provide sample quantities (100g to 1kg) for laboratory verification, complete with lot-specific Certificate of Analysis (CoA), MSDS, HPLC chromatograms, and 1H-NMR spectrum validation.
Thanks to our 250,000 m² factory capacity and raw material integration, standard multi-ton orders are processed and dispatched within 10 to 14 business days from our China manufacturing facility.
Gentolex maintains direct operational representatives in Mexico and South Africa, providing localized client consultation, seamless customs clearance guidance, and local currency billing options.
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